NUP98
NUP98 is a gene that in humans is encoded by the NUP98 nuclear pore complex protein. It is involved in the transport of proteins between the nucleus and the cytoplasm. Mutations in this gene are associated with several types of leukemia.
Function[edit | edit source]
The NUP98 gene provides instructions for making a protein that is found in the nuclear pore complex, a structure that regulates the movement of molecules into and out of the nucleus of the cell. The NUP98 protein plays a crucial role in the transport of proteins and RNA molecules between the nucleus and the cytoplasm.
Clinical significance[edit | edit source]
Mutations in the NUP98 gene have been associated with several types of leukemia, including acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). These mutations often result in the production of an abnormal fusion protein that disrupts the normal function of the cell, leading to the development of leukemia.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- NUP98 at the Genetics Home Reference
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Contributors: Prab R. Tumpati, MD
