Nafoxidine
Nafoxidine is a nonsteroidal SERM that was previously under investigation for potential medical applications but was never marketed. It is structurally related to tamoxifen, another SERM that is widely used for the treatment of breast cancer.
Chemistry[edit | edit source]
Nafoxidine is a nonsteroidal compound, meaning it does not have a steroid backbone structure common to steroid hormones like estrogen. Instead, it has a phenyl group, a piperidine ring, and a naphthalene ring, which together form a unique structure that allows it to bind to estrogen receptors.
Pharmacology[edit | edit source]
Nafoxidine acts as a SERM, or selective estrogen receptor modulator. This means it can act as an agonist or antagonist of the estrogen receptor depending on the tissue type. In some tissues, such as the breast, it acts as an antagonist, blocking the effects of estrogen and potentially helping to prevent or treat estrogen-sensitive cancers. In other tissues, such as the bone and cardiovascular system, it acts as an agonist, mimicking the effects of estrogen and potentially providing beneficial effects.
Clinical Development[edit | edit source]
Nafoxidine was initially developed in the 1970s and underwent clinical trials for the treatment of breast cancer. However, it was found to cause cataracts in animal studies, which led to its development being discontinued. Despite this, it has been used in research settings to study the function of estrogen receptors and the effects of SERMs.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
