Naftifine

Naftifine is an antifungal medication used primarily to treat skin infections. It belongs to the class of drugs known as allylamine antifungals, which work by inhibiting the enzyme squalene epoxidase, disrupting the synthesis of ergosterol, a vital component of fungal cell membranes.

Pharmacology

Naftifine is a synthetic, broad-spectrum antifungal agent. It exhibits fungicidal activity in vitro against a wide range of pathogenic fungi, including dermatophytes, yeasts, and molds. The primary mode of action of naftifine is the inhibition of squalene epoxidase, an enzyme involved in the biosynthesis of ergosterol. This inhibition leads to a decrease in ergosterol and an accumulation of squalene within the fungal cell, resulting in cell death.

Clinical Use

Naftifine is used topically to treat fungal infections of the skin, such as athlete's foot, jock itch, and ringworm. It is also effective against Candida species and Pityrosporum species, which can cause seborrheic dermatitis and tinea versicolor, respectively.

Side Effects

Common side effects of naftifine include redness, itching, stinging, burning, or irritation at the application site. These side effects are usually mild and temporary. However, if they persist or worsen, medical attention should be sought.

Precautions

Before using naftifine, it is important to inform the healthcare provider about any allergies, medical history, and current medications. It should not be used on the face, groin, or underarms unless directed by a healthcare provider.

See Also

• Antifungal medication
• Allylamine antifungals
• Squalene epoxidase
• Ergosterol
• Athlete's foot
• Jock itch
• Ringworm
• Candida
• Pityrosporum
• Seborrheic dermatitis
• Tinea versicolor