Naftifine hydrochloride

Naftifine hydrochloride is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is primarily used in the treatment of fungal infections of the skin, such as athlete's foot, jock itch, and ringworm.

Chemistry

Naftifine hydrochloride is chemically known as (E)-N-Cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride. It is a white to off-white crystalline powder that is freely soluble in methanol, ethanol, and chloroform, and slightly soluble in water.

Mechanism of Action

Naftifine hydrochloride exhibits fungicidal activity in vitro against a broad spectrum of dermatophytes. It interferes with the biosynthesis of ergosterol, a critical component of fungal cell membranes, and inhibits the enzyme squalene epoxidase, leading to cell death.

Clinical Use

Naftifine hydrochloride is indicated for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis.

Side Effects

Common side effects of naftifine hydrochloride include redness, itching, stinging, burning, or irritation at the application site. Severe allergic reactions are rare but can occur.

Precautions

Naftifine hydrochloride is for external use only and should not be used on the face, groin, or underarms unless directed by a healthcare professional. It should not be used in the eyes, nose, mouth, or vagina.

See Also

• Antifungal medication
• Dermatophyte
• Ergosterol
• Squalene epoxidase