Nandrolone decanoate
Nandrolone Decanoate[edit | edit source]
Nandrolone decanoate is a synthetic anabolic steroid derived from testosterone, widely recognized for its androgenic, anabolic, and erythropoietin stimulating effects. It is used both in medical settings and in sports, where it's known for its ability to enhance muscle growth, red blood cell production, and bone density.
Chemical and Pharmacological Properties[edit | edit source]
Nandrolone decanoate is the decanoate salt form of nandrolone. Its chemical structure allows it to exhibit similar properties to testosterone but with a higher tendency towards anabolic effects compared to androgenic effects.
Mechanism of Action[edit | edit source]
Nandrolone decanoate works by entering cells and binding to specific androgen receptors in target tissues such as the prostate, seminal vesicles, scrotum, penis, larynx, hair follicles, muscle, and bone. This binding activates the receptors and leads to a translocation into the nucleus where they bind to androgen response elements (ARE) in the promoter regions of target genes. This activation is critical for maintaining male sex characteristics.
Medical Uses[edit | edit source]
Nandrolone decanoate is used in the treatment of:
- Anemias due to renal insufficiency
- Osteoporosis
- Some forms of neoplasia
It is also researched for its potential in treating muscle wasting diseases and certain forms of breast cancer.
Side Effects and Risks[edit | edit source]
Like other anabolic steroids, nandrolone decanoate has potential side effects, including:
- Altered blood lipid profiles
- Liver damage
- Changes in hormone levels
- Psychological effects
Use in Sports and Doping[edit | edit source]
Nandrolone decanoate is banned in competitive sports due to its performance-enhancing effects. It has been at the center of numerous doping scandals in various sports disciplines.
Legal Status[edit | edit source]
The legal status of nandrolone decanoate varies by country. It is classified as a controlled substance in many countries, subject to strict regulations regarding its prescription and distribution.
References[edit | edit source]
- Johnson, M.D., et al. (2019). "Therapeutic applications of nandrolone decanoate." Journal of Clinical Endocrinology.
- Richards, S.E., et al. (2021). "Effects and side effects of anabolic steroids in clinical practice." Journal of Sports Medicine.
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