Narasin

Narasin

Narasin is an ionophore antibiotic used primarily in veterinary medicine. It is produced by the bacterium Streptomyces aureofaciens and is used as a coccidiostat in poultry and as a growth promoter in cattle.

History

Narasin was first isolated in the 1970s from Streptomyces aureofaciens. It was initially used as a coccidiostat in poultry, but its use has since expanded to include growth promotion in cattle.

Mechanism of Action

Narasin works by increasing the permeability of the cell membrane to certain ions, particularly sodium and potassium. This disrupts the normal functioning of the cell, leading to the death of the parasite.

Use in Veterinary Medicine

In poultry, narasin is used to prevent and treat coccidiosis, a common parasitic disease. It is also used as a growth promoter in cattle, as it improves feed efficiency and weight gain.

Safety and Side Effects

Narasin is generally considered safe for use in animals. However, it can be toxic to horses and other equines, and should not be used in these species. Side effects in other animals are rare, but can include reduced feed intake and weight gain.

Regulatory Status

In the United States, narasin is approved for use in poultry and cattle by the Food and Drug Administration (FDA). In the European Union, it is approved for use in poultry, but not in cattle.

See Also

• Ionophore
• Coccidiostat
• Veterinary Medicine
• Streptomyces aureofaciens

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