Mixed lineage kinase domain like pseudokinase

Mixed Lineage Kinase Domain Like Pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. It is a key component in the process of necroptosis, a form of programmed cell death.

Function

MLKL is a pseudokinase, meaning it has a similar structure to kinases but lacks the enzymatic activity. It is activated by RIPK3 (Receptor-interacting serine/threonine-protein kinase 3), another protein involved in necroptosis. Upon activation, MLKL translocates to the cell membrane where it forms pores, leading to cell swelling and eventual rupture, a hallmark of necroptosis.

Clinical Significance

MLKL and the process of necroptosis have been implicated in a variety of diseases, including neurodegenerative diseases, inflammatory diseases, and cancer. Inhibition of MLKL could therefore be a potential therapeutic strategy in these conditions.

Research

Research into MLKL and necroptosis is ongoing, with studies focusing on understanding the precise mechanisms of MLKL activation and its role in disease. This research could lead to the development of new drugs targeting MLKL and necroptosis.

See Also

• Necroptosis
• Pseudokinase
• RIPK3
• Programmed cell death