Neonatal cholestasis

Neonatal cholestasis is a condition that occurs in newborns, where the bile flow from the liver is reduced or blocked. This can lead to a variety of health problems, including liver damage and failure. The condition is often diagnosed in the first few months of life.

Causes

Neonatal cholestasis can be caused by a variety of factors. These include genetic disorders, infections, metabolic disorders, and structural abnormalities of the liver or bile ducts. Some of the most common causes include biliary atresia, Alagille syndrome, and cystic fibrosis.

Symptoms

The most common symptom of neonatal cholestasis is jaundice, which is a yellowing of the skin and eyes. Other symptoms can include dark urine, pale stools, and an enlarged liver. In some cases, the condition can also cause poor growth and development.

Diagnosis

Diagnosis of neonatal cholestasis typically involves a combination of physical examination, medical history, and laboratory tests. These tests can include blood tests, imaging studies, and in some cases, a liver biopsy.

Treatment

Treatment for neonatal cholestasis depends on the underlying cause. In some cases, surgery may be necessary to correct structural abnormalities. Medications may also be used to improve bile flow and reduce the risk of liver damage. In severe cases, a liver transplant may be necessary.

Prognosis

The prognosis for neonatal cholestasis varies depending on the underlying cause and the severity of the condition. With early diagnosis and treatment, many children with this condition can lead normal, healthy lives.

See also

• Liver disease
• Pediatric gastroenterology

Neonatal cholestasis Resources
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