Neuregulin-1

Neuregulin 1
Identifiers
Symbol	NRG1
NCBI gene	3084
HGNC	7998
OMIM	142445
RefSeq	NM_013956
UniProt	Q02297
Other data
Locus	Chr. 8 p12
Search for Structures Swiss-model Domains InterPro

Neuregulin-1 (NRG1) is a protein that plays a critical role in the development and functioning of several systems within the body, particularly the nervous system. It is one of the members of the neuregulin family of growth and differentiation factors that act through the ErbB family of tyrosine kinase receptors.

Function

NRG1 is involved in a variety of cellular processes, including cell communication, growth, and differentiation. It is essential for the development of the heart and the nervous system. In the nervous system, NRG1 is critical for the development of the myelin sheath, the protective covering that surrounds nerve fibers. This protein is also involved in the synaptic plasticity, which is essential for cognitive functions such as learning and memory.

Structure

The NRG1 gene is located on chromosome 8p12 and is known to have numerous isoforms, which arise due to alternative splicing. These isoforms can be grouped into type I, II, III, and IV, each having different functions and being expressed in different tissues.

Clinical Significance

Alterations in the expression or function of NRG1 or its receptors have been implicated in several neurological disorders, including schizophrenia and multiple sclerosis. NRG1 is also studied for its role in cardiac function, and its potential therapeutic implications in heart disease.

Research

Research on NRG1 has focused on its potential therapeutic applications, particularly in neurodegenerative diseases and psychiatric conditions. Studies have explored how modulating NRG1 signaling pathways could potentially lead to new treatments for these diseases.

See Also

• ErbB
• Schizophrenia
• Myelin
• Multiple sclerosis