Neurolemma

Neurolemma (also known as the neurilemma or Sheath of Schwann) is the outermost layer of a nerve fiber in the peripheral nervous system. It is composed of Schwann cells, which provide support and protection for the nerve fibers. The neurolemma plays a crucial role in the process of nerve regeneration.

Structure

The neurolemma is made up of Schwann cells, which wrap around the nerve fiber and form a protective layer. This layer is essential for the survival and function of the nerve fiber. The neurolemma is not present in the central nervous system, where the nerve fibers are instead myelinated by oligodendrocytes.

Function

The primary function of the neurolemma is to support and protect the nerve fibers. It also plays a crucial role in the process of nerve regeneration. When a nerve fiber is damaged, the neurolemma helps to guide the growth of the new nerve fiber.

Clinical significance

Damage to the neurolemma can lead to a variety of neurological disorders, including peripheral neuropathy and Charcot-Marie-Tooth disease. In addition, the absence of the neurolemma in the central nervous system is one of the reasons why nerve regeneration is more difficult in this part of the nervous system.

See also

• Myelin sheath
• Nerve regeneration
• Schwann cell
• Peripheral nervous system

References

Neurolemma Resources
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