Neuropeptide FF receptor
Neuropeptide FF receptor is a type of G protein-coupled receptor that is activated by the neuropeptide FF (NPFF). There are two known subtypes of this receptor, Neuropeptide FF receptor 1 (NPFF1) and Neuropeptide FF receptor 2 (NPFF2), both of which are involved in a variety of physiological processes.
Structure[edit | edit source]
Neuropeptide FF receptors are integral membrane proteins that are composed of seven transmembrane domains. Like other G protein-coupled receptors, they have an extracellular N-terminus, an intracellular C-terminus, and three extracellular and three intracellular loops. The binding site for NPFF is located within the transmembrane domains.
Function[edit | edit source]
Neuropeptide FF receptors are widely distributed in the central nervous system, particularly in areas involved in pain modulation and cardiovascular control. They are also found in peripheral tissues, including the heart and blood vessels.
Activation of NPFF receptors by NPFF leads to the inhibition of adenylate cyclase, resulting in decreased levels of cyclic AMP. This can have a variety of effects, depending on the specific cell type and physiological context. For example, in neurons, this can lead to hyperpolarization and decreased excitability.
In addition to their role in pain modulation and cardiovascular control, NPFF receptors have been implicated in a variety of other physiological processes, including feeding behavior, stress response, and the regulation of hormone release.
Clinical significance[edit | edit source]
Due to their involvement in pain modulation, NPFF receptors have been investigated as potential targets for the development of new analgesic drugs. In addition, their role in feeding behavior and stress response suggests that they may also be potential targets for the treatment of eating disorders and stress-related conditions.
See also[edit | edit source]
This GPCR-related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD