Neurulation

Neurulation is a fundamental process in early embryonic development, involving the formation of the neural tube. This structure eventually develops into the central nervous system, comprising the brain and spinal cord. Neurulation is a complex process that involves a series of coordinated morphological changes in the embryo.

Stages of Neurulation

Neurulation can be divided into two main stages: primary neurulation and secondary neurulation.

Primary Neurulation

Primary neurulation involves the formation of the neural tube from the neural plate, a thickened region of the ectoderm. The edges of the neural plate start to thicken and elevate to form the neural folds. The neural folds then converge and fuse to form the neural tube.

Secondary Neurulation

Secondary neurulation involves the formation of the neural tube from a solid cord of cells that sinks into the embryo and subsequently hollows out (cavitates) to form a tube.

Molecular Mechanisms of Neurulation

The process of neurulation is controlled by a complex interplay of gene expression, cell signaling, and morphogenetic movements. Key molecules involved in this process include Sonic hedgehog (Shh), bone morphogenetic proteins (BMPs), and fibroblast growth factors (FGFs).

Clinical Significance

Abnormalities in neurulation can lead to severe congenital malformations, collectively referred to as neural tube defects (NTDs). These include conditions such as anencephaly, spina bifida, and encephalocele.

See Also

• Gastrulation
• Organogenesis
• Neural crest

References

Neurulation Resources
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