Neurotensin receptor 2

Neurotensin receptor 2 (NTR2) is a protein that in humans is encoded by the NTSR2 gene. It is a member of the neurotensin receptor family, which is a group of G protein-coupled receptors that are involved in various physiological processes.

Function

Neurotensin receptor 2 is a high affinity receptor for the neurotensin peptide. Neurotensin is a 13 amino acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor. Neurotensin receptor 2 is less understood than its counterpart, neurotensin receptor 1, but it is known to be involved in regulating pain perception, body temperature, and possibly some endocrine functions.

Clinical significance

Alterations in the function of neurotensin receptor 2 have been implicated in a variety of diseases, including schizophrenia, Parkinson's disease, and certain types of cancer. In particular, overexpression of neurotensin receptor 2 has been observed in certain types of breast and prostate cancers.

See also

• Neurotensin receptor
• Neurotensin
• G protein-coupled receptor
• Schizophrenia
• Parkinson's disease
• Cancer

References

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