Neurotensin receptor 2
Neurotensin receptor 2 (NTR2) is a protein that in humans is encoded by the NTSR2 gene. It is a member of the neurotensin receptor family, which is a group of G protein-coupled receptors that are involved in various physiological processes.
Function[edit | edit source]
Neurotensin receptor 2 is a high affinity receptor for the neurotensin peptide. Neurotensin is a 13 amino acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor. Neurotensin receptor 2 is less understood than its counterpart, neurotensin receptor 1, but it is known to be involved in regulating pain perception, body temperature, and possibly some endocrine functions.
Clinical significance[edit | edit source]
Alterations in the function of neurotensin receptor 2 have been implicated in a variety of diseases, including schizophrenia, Parkinson's disease, and certain types of cancer. In particular, overexpression of neurotensin receptor 2 has been observed in certain types of breast and prostate cancers.
See also[edit | edit source]
- Neurotensin receptor
- Neurotensin
- G protein-coupled receptor
- Schizophrenia
- Parkinson's disease
- Cancer
References[edit | edit source]
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