Neutrophil elastase

Identifiers
EC number	3.4.21.37
CAS number	9004-06-2
Alt. names
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway

Neutrophil elastase is a serine protease enzyme that is primarily found in neutrophils, a type of white blood cell. It plays a crucial role in the immune system by breaking down proteins and peptides during the process of phagocytosis.

Function

Neutrophil elastase is involved in the degradation of various extracellular matrix proteins, including elastin, collagen, and fibronectin. This activity is essential for the immune response, allowing neutrophils to migrate through tissues to reach sites of infection or inflammation.

Clinical Significance

Excessive activity of neutrophil elastase can lead to tissue damage and is associated with several diseases. For example, in chronic obstructive pulmonary disease (COPD), the enzyme contributes to the destruction of lung tissue. In cystic fibrosis, neutrophil elastase is involved in the degradation of lung epithelial cells, exacerbating the disease.

Regulation

The activity of neutrophil elastase is tightly regulated by endogenous inhibitors such as alpha-1 antitrypsin. A deficiency in alpha-1 antitrypsin can lead to unregulated activity of neutrophil elastase, resulting in conditions like emphysema.

Therapeutic Target

Neutrophil elastase is a target for therapeutic intervention in diseases where its activity is detrimental. Inhibitors of neutrophil elastase are being developed to treat conditions such as COPD and cystic fibrosis.

See Also

• Serine protease
• Alpha-1 antitrypsin
• Chronic obstructive pulmonary disease
• Cystic fibrosis

External Links

• Neutrophil elastase on WikiMD