Somatrogon
(Redirected from Ngenla)
Somatrogon is a long-acting recombinant human growth hormone (rhGH) used in the treatment of growth hormone deficiency (GHD) in children and adults. It is designed to provide a more convenient dosing regimen compared to daily growth hormone injections.
Mechanism of Action[edit | edit source]
Somatrogon works by stimulating growth and cell reproduction in humans. It binds to the growth hormone receptor (GHR) on the surface of target cells, activating intracellular signaling pathways that promote growth and development. The long-acting nature of Somatrogon is achieved through the fusion of the growth hormone with a carrier protein, which extends its half-life in the bloodstream.
Indications[edit | edit source]
Somatrogon is primarily indicated for:
- Growth hormone deficiency in pediatric patients
- Growth hormone deficiency in adult patients
Administration[edit | edit source]
Somatrogon is administered via subcutaneous injection. The dosing frequency is typically once weekly, which is a significant improvement over the daily injections required for traditional growth hormone therapies.
Side Effects[edit | edit source]
Common side effects of Somatrogon include:
- Injection site reactions
- Headache
- Nausea
- Muscle pain
Serious side effects may include:
- Increased intracranial pressure
- Hyperglycemia
- Hypothyroidism
Pharmacokinetics[edit | edit source]
The pharmacokinetics of Somatrogon involve a prolonged half-life due to its molecular structure, allowing for sustained release and activity in the body. This results in stable growth hormone levels with less frequent dosing.
Related Pages[edit | edit source]
- Growth hormone
- Growth hormone receptor
- Growth hormone deficiency
- Recombinant DNA
- Subcutaneous injection
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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