Somatropin
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Somatropin is a form of human growth hormone important for the growth of bones and muscles. It is used to treat growth hormone deficiency and certain conditions that cause short stature, such as Turner syndrome, chronic kidney disease, Prader-Willi syndrome, and children who are small for gestational age.
Medical uses[edit | edit source]
Somatropin is indicated for multiple conditions, including:
- Growth hormone deficiency in children and adults
- Turner syndrome
- Chronic kidney disease
- Prader-Willi syndrome
- Children who were small for gestational age
Mechanism of action[edit | edit source]
Somatropin works by mimicking the effects of natural growth hormone, which is produced by the pituitary gland. It binds to growth hormone receptors on cells, which stimulates cell growth, reproduction, and regeneration.
Administration[edit | edit source]
Somatropin is administered through subcutaneous or intramuscular injections. The dosage and frequency of administration depend on the age, weight, and condition being treated.
Side effects[edit | edit source]
Common side effects of somatropin include:
- Injection site reactions
- Muscle pain
- Joint pain
- Headaches
- Increased risk of diabetes
More serious side effects may include increased risk of cancer, particularly in those who have undergone radiation treatment to the brain.
Pharmacokinetics[edit | edit source]
Somatropin has a high bioavailability when administered intravenously and slightly lower when administered subcutaneously. It is metabolized primarily in the liver and excreted by the kidneys.
Regulation[edit | edit source]
Somatropin is classified as a prescription medication and is regulated by various national drug agencies. Its use in sports is banned by most major sporting bodies due to its muscle-building properties.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD