Nicocodeine

Nicocodeine is an opioid analgesic and cough suppressant, an ester of codeine closely related to dihydrocodeine and the codeine analogue of nicomorphine. It is not commonly used in most countries, but has activity similar to other opioids. Nicocodeine and nicomorphine were introduced in the 1950s by Lannacher Heilmittel of Austria.

Pharmacology

Nicocodeine is metabolised in the liver by demethylation to produce nicomorphine, also known as 6-nicotinoylmorphine, and then further to morphine. Side effects are similar to those of other opioids and include itching, nausea and respiratory depression.

Chemistry

Nicocodeine is almost always used as the hydrochloride salt, which has a free base conversion ratio of 0.914.

Legal status

Nicocodeine is regulated in much the same way as codeine, but unlike most other prescription opioids, tablets as well as cough syrups are available. Nicocodeine is a Schedule II drug under the Single Convention on Narcotic Drugs.

See also

• Hydrocodone
• Dihydrocodeine
• Nicomorphine
• Oxycodone

References

Nicocodeine Resources
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