Niflumic acid

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

(Redirected from Niflumic Acid)

A non-steroidal anti-inflammatory drug


Niflumic acid
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG


Niflumic acid is a non-steroidal anti-inflammatory drug (NSAID) used primarily for its analgesic and anti-inflammatory properties. It is part of the fenamate class of NSAIDs, which are derivatives of anthranilic acid.

Pharmacology[edit | edit source]

Niflumic acid works by inhibiting the cyclooxygenase (COX) enzymes, which are key in the synthesis of prostaglandins. Prostaglandins are lipid compounds that have several important roles in the body, including the mediation of inflammation and pain. By reducing the production of prostaglandins, niflumic acid helps alleviate symptoms of pain and inflammation.

Medical uses[edit | edit source]

Niflumic acid is used to treat a variety of conditions associated with pain and inflammation, such as:

Side effects[edit | edit source]

Like other NSAIDs, niflumic acid can cause a range of side effects. Common side effects include:

More serious side effects can occur, such as:

Mechanism of action[edit | edit source]

Chemical structure of Niflumic acid

Niflumic acid inhibits both COX-1 and COX-2 enzymes, though it has a higher affinity for COX-2. This selective inhibition helps reduce inflammation and pain while minimizing gastrointestinal side effects associated with COX-1 inhibition.

Chemistry[edit | edit source]

Niflumic acid is chemically classified as a fenamate, which is a derivative of anthranilic acid. Its chemical structure includes a trifluoromethyl group, which is believed to contribute to its pharmacological activity.

History[edit | edit source]

Niflumic acid was first introduced in the 1970s and has been used in various countries for the treatment of inflammatory conditions. It is not as widely used as some other NSAIDs, but it remains an important option for patients who require alternative anti-inflammatory medications.

Related pages[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD