Nisterime acetate

Nisterime Acetate is a synthetic, steroidal estrogen that was developed for medical use but was never marketed. It is an estrogen ester, specifically, an ester of ethinylestradiol. Nisterime acetate is related to other esterified estrogens like estradiol valerate and estradiol cypionate.

Chemistry

Nisterime acetate, also known as 17α-ethynylestradiol 3-cyclopentylpropionate, is a synthetic estrane steroid and a derivative of estradiol. It is more specifically a derivative of ethinylestradiol, which itself is a 17α-ethynylated and hence synthetic variant of estradiol.

Pharmacology

As an estrogen, nisterime acetate has feminizing effects on the body. It is an estrogen ester, and acts as a prodrug to ethinylestradiol in the body. Because it is a prodrug, it needs to be metabolized in the body to release the active hormone.

History

Nisterime acetate was developed in the 1960s but was never marketed. The reason for its lack of marketing is not entirely clear, but may be related to its pharmacokinetic properties or potential side effects.

See also

• List of estrogen esters
• List of synthetic estrogens