Nitromifene

Nitromifene is a nonsteroidal selective estrogen receptor modulator (SERM) that was never marketed. It is a derivative of triphenylethylene and is related to other triphenylethylene SERMs such as clomifene and tamoxifen.

Chemistry

Nitromifene is a synthetic, nonsteroidal compound of the triphenylethylene group. It is structurally related to other triphenylethylene SERMs such as clomifene and tamoxifen, with the primary difference being the presence of a nitro group in nitromifene.

Pharmacology

As a SERM, nitromifene acts as an agonist or antagonist of the estrogen receptor (ER), depending on the tissue type. In some tissues, it can block the effects of naturally occurring estrogen, while in others it can mimic these effects. This selective action is what gives SERMs their name and distinguishes them from other types of estrogen receptor modulators.

Clinical significance

Although nitromifene was never marketed, it has been the subject of scientific research. Studies have investigated its potential use in the treatment of breast cancer, due to its ability to block the effects of estrogen in breast tissue. However, further research is needed to fully understand its efficacy and safety profile.

See also

• Selective estrogen receptor modulator
• Triphenylethylene
• Clomifene
• Tamoxifen

References

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