Nivacortol
Nivacortol is a synthetic glucocorticoid, a type of steroid used in the treatment of various inflammatory and autoimmune conditions. It is a derivative of prednisolone, and is also known by its systematic name, 21-(acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione.
Pharmacology[edit | edit source]
Nivacortol, like other glucocorticoids, works by binding to the glucocorticoid receptor in the cytoplasm of target cells. This binding triggers a series of events that ultimately leads to the suppression of inflammation and the immune response. The drug has potent anti-inflammatory and immunosuppressive properties, making it useful in the treatment of a wide range of conditions.
Clinical Use[edit | edit source]
Nivacortol is used in the treatment of various inflammatory and autoimmune conditions, including rheumatoid arthritis, asthma, and lupus erythematosus. It can also be used to suppress the immune system in patients undergoing organ transplantation, to prevent organ rejection.
Side Effects[edit | edit source]
Like other glucocorticoids, Nivacortol can have a number of side effects. These can include weight gain, osteoporosis, glaucoma, and Cushing's syndrome. Long-term use of the drug can also lead to adrenal insufficiency.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD