Norendoxifen

Norendoxifen is an active metabolite of the drug tamoxifen, which is widely used in the treatment of breast cancer. It is a selective estrogen receptor modulator (SERM) with antiestrogenic properties.

Pharmacology

Norendoxifen is a potent and selective estrogen receptor (ER) antagonist. It binds to the ER and prevents the binding of estrogen, thereby inhibiting the growth of ER-positive breast cancer cells. Norendoxifen is more potent than tamoxifen in inhibiting the growth of breast cancer cells and has a similar potency to endoxifen, another active metabolite of tamoxifen.

Clinical significance

Norendoxifen has been found to be present in the blood of patients treated with tamoxifen. The levels of norendoxifen in the blood can vary widely among individuals, which may affect the effectiveness of tamoxifen treatment. Studies have suggested that measuring the levels of norendoxifen and other tamoxifen metabolites in the blood could be useful in predicting the response to tamoxifen treatment.

See also

• Tamoxifen
• Endoxifen
• Selective estrogen receptor modulator
• Breast cancer

Norendoxifen Resources
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