Triphenylethylene

Triphenylethylene is a chemical compound that serves as the basic structure for a class of drugs known as selective estrogen receptor modulators (SERMs). These drugs are used in the treatment of various medical conditions, including breast cancer and osteoporosis.

Structure and Properties

Triphenylethylene is composed of a central ethylene group surrounded by three phenyl groups. This structure gives the compound its unique properties, including its ability to bind to estrogen receptors.

Medical Uses

Triphenylethylene derivatives, such as tamoxifen and clomifene, are used in the treatment of various medical conditions. Tamoxifen is primarily used in the treatment of breast cancer, while clomifene is used in the treatment of infertility in women.

Mechanism of Action

Triphenylethylene derivatives work by binding to estrogen receptors in the body. This binding can either activate or inhibit the receptors, depending on the specific drug and the tissue in which the receptor is located. This selective action is what gives these drugs their name - selective estrogen receptor modulators.

Side Effects

Like all drugs, triphenylethylene derivatives can cause side effects. These can include hot flashes, nausea, and vaginal discharge. In rare cases, these drugs can also increase the risk of endometrial cancer.

See Also

• Selective estrogen receptor modulator
• Tamoxifen
• Clomifene

Triphenylethylene Resources
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