Norpsilocin

Norpsilocin

Norpsilocin is a tryptamine alkaloid found in certain species of psilocybin mushrooms. It is a dephosphorylated metabolite of psilocybin, and also a phosphorylated form of bæocystin. Norpsilocin is a lesser-known compound but is becoming increasingly studied due to its potential therapeutic uses.

Chemistry

Norpsilocin is a tryptamine alkaloid, meaning it is structurally similar to the neurotransmitter serotonin. It is a monoamine, which refers to its single amine group. The chemical formula of norpsilocin is C12H16N2O.

Biosynthesis

The biosynthesis of norpsilocin in psilocybin mushrooms is not fully understood. It is believed to be synthesized from tryptophan via a series of enzymatic reactions. The final step in the biosynthesis of norpsilocin is the dephosphorylation of psilocybin, which is catalyzed by the enzyme alkaline phosphatase.

Pharmacology

Norpsilocin is believed to act as a partial agonist at the 5-HT2A receptor, the primary target of psilocybin. This receptor is involved in the regulation of mood, cognition, and perception. The pharmacological effects of norpsilocin are not well-studied, but it is believed to contribute to the psychoactive effects of psilocybin mushrooms.

Therapeutic Potential

Research into the therapeutic potential of norpsilocin is in its early stages. However, due to its structural and pharmacological similarities to psilocybin, it is believed that norpsilocin may have potential in the treatment of various psychiatric disorders, including depression, anxiety, and post-traumatic stress disorder (PTSD).

See Also

• Psilocybin
• Psilocin
• Bæocystin
• Tryptamine