Alkaline phosphatase

1ALK

PDB 1alk EBI.jpg

Enzyme related to dephosphorylation

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Identifiers
EC number	3.1.3.1
CAS number	9001-78-9
Alt. names
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway

Alkaline phosphatase (ALP) is an enzyme that is found in many tissues throughout the body, including the liver, bone, kidney, and placenta. It is involved in the process of dephosphorylation, which is the removal of a phosphate group from a molecule.

Function

Alkaline phosphatase plays a crucial role in metabolism and signal transduction by dephosphorylating molecules such as nucleotides, proteins, and alkaloids. This enzyme is most active in an alkaline environment, hence its name.

Isoenzymes

There are several isoenzymes of alkaline phosphatase, which are classified based on their tissue of origin:

• Liver alkaline phosphatase
• Bone alkaline phosphatase
• Intestinal alkaline phosphatase
• Placental alkaline phosphatase

Clinical significance

Elevated levels of alkaline phosphatase in the blood can indicate various medical conditions, including liver disease, bone disorders, and biliary obstruction. Conversely, low levels of ALP can be associated with conditions such as hypophosphatasia.

Diagnostic use

Alkaline phosphatase levels are commonly measured in blood tests to help diagnose and monitor diseases. The test is often part of a liver function test panel.

Related enzymes

Alkaline phosphatase is part of a larger family of phosphatases, which includes:

• Acid phosphatase
• Protein phosphatase

See also

• Liver function tests
• Bone metabolism
• Enzyme kinetics