Norsalsolinol

Norsalsolinol is a chemical compound that is a precursor to the neurotoxin salsolinol. It is formed in the body from dopamine and acetaldehyde, a metabolite of ethanol. Norsalsolinol has been implicated in the development of Parkinson's disease and alcoholism.

Formation

Norsalsolinol is formed in the body from dopamine and acetaldehyde. This reaction is catalyzed by the enzyme CYP2E1. The formation of norsalsolinol is increased in the presence of ethanol, which is metabolized to acetaldehyde by the enzyme alcohol dehydrogenase.

Role in disease

Norsalsolinol has been implicated in the development of Parkinson's disease and alcoholism. In Parkinson's disease, it is thought to contribute to the death of dopaminergic neurons in the substantia nigra, a region of the brain that is affected in this disease. In alcoholism, norsalsolinol may contribute to the neurotoxic effects of ethanol.

See also

• Salsolinol
• Dopamine
• Acetaldehyde
• Parkinson's disease
• Alcoholism

References

Norsalsolinol Resources
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