Nucleoporin 153

Nucleoporin 153 (NUP153) is a protein that in humans is encoded by the NUP153 gene. It is a component of the nuclear pore complex, a structure that regulates the transport of molecules between the nucleus and the cytoplasm.

Function

NUP153 is a key component of the nuclear pore complex (NPC). The NPC is a large multiprotein complex that spans the nuclear envelope and allows the transport of molecules between the nucleus and the cytoplasm. NUP153 is located on the nuclear side of the NPC and plays a crucial role in nuclear import and export.

Structure

The NUP153 protein is a large, flexible protein that contains multiple domains. The N-terminal region of the protein contains a series of phenylalanine-glycine (FG) repeats, which are thought to form a hydrophobic meshwork that facilitates the transport of molecules through the NPC. The C-terminal region of the protein contains a zinc finger domain, which is thought to be involved in protein-protein interactions.

Clinical significance

Mutations in the NUP153 gene have been associated with several diseases, including Hutchinson-Gilford progeria syndrome, a rare genetic disorder characterized by rapid aging. In addition, alterations in NUP153 expression have been observed in several types of cancer, suggesting a potential role for this protein in tumorigenesis.

See also

• Nuclear pore
• Nucleoporin
• Hutchinson-Gilford progeria syndrome

References

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