Nucleoporin 85

Nucleoporin 85 (also known as Nup85) is a protein that in humans is encoded by the NUP85 gene. It is a component of the nuclear pore complex, a structure that regulates the transport of molecules between the nucleus and the cytoplasm in eukaryotic cells.

Function

Nucleoporin 85 is a part of the nuclear pore complex, which is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nup85 is a component of the Nup107-160 subcomplex, which is a critical part of the nuclear pore complex.

Structure

The NUP85 gene encodes a protein that is a member of the nucleoporin family. The encoded protein contains a Nup85 domain, which is characteristic of proteins involved in nuclear pore complex assembly. The protein also has a coiled-coil domain, which is a common structural motif in proteins that are involved in various biological functions, including protein-protein interactions.

Clinical significance

Mutations in the NUP85 gene have been associated with several diseases, including leukemia and cancer. Research has shown that alterations in the expression of NUP85 can lead to changes in nuclear pore complex function, which can in turn affect the regulation of gene expression and cell cycle progression.

See also

• Nuclear pore
• Nucleoporin
• Nup107-160 subcomplex

References

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