ONECUT1

ONECUT1 is a gene that in humans is encoded by the ONECUT1 protein. This gene is also known as Hepatocyte Nuclear Factor 6 (HNF-6) and OC-1. It is a member of the ONECUT class of homeodomain transcription factors.

Function

The ONECUT1 gene is a transcription factor that is involved in the regulation of liver development, pancreas development, and neurogenesis. It is expressed in the developing liver and pancreas, as well as in the central nervous system (CNS). In the CNS, ONECUT1 is involved in the differentiation of dopaminergic neurons, which are important for motor control and reward system.

Clinical significance

Mutations in the ONECUT1 gene have been associated with several diseases. For example, a mutation in this gene has been linked to congenital hyperinsulinism, a condition characterized by excessive insulin secretion. Additionally, alterations in ONECUT1 expression have been implicated in hepatocellular carcinoma, the most common type of liver cancer.

Research

Research on ONECUT1 is ongoing, with studies investigating its role in various biological processes and diseases. For instance, recent research has suggested that ONECUT1 may play a role in the development of Parkinson's disease, as it is involved in the differentiation of dopaminergic neurons, which are affected in this condition.

See also

• ONECUT2
• ONECUT3
• Homeobox

References

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