OR1L1

OR1L1 is a gene that encodes the olfactory receptor 1L1 in humans. The olfactory receptor family is believed to be the largest gene family in the human genome. These receptors are responsible for the detection of odor molecules, playing a crucial role in the sense of smell.

Function

The OR1L1 gene belongs to the olfactory receptor gene family, which is a part of the G protein-coupled receptor superfamily. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response, resulting in the perception of a smell. The OR1L1 gene provides instructions for making a protein that is found in cells of the olfactory epithelium, the tissue lining the nasal cavity.

Structure

The OR1L1 gene is located on the chromosome 1 (1q44). It spans about 1 kilobase and consists of a single coding exon. The OR1L1 protein is a member of the class A rhodopsin-like family of G protein-coupled receptors.

Clinical Significance

While the specific clinical significance of OR1L1 is not yet fully understood, olfactory receptors in general are being studied for their potential roles in disease. For example, changes in the sense of smell can be an early sign of Parkinson's disease or Alzheimer's disease. More research is needed to understand the potential implications of OR1L1 in human health and disease.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 1

References

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