OR2G6

OR2G6 is a gene that encodes a protein in the olfactory receptor family. The olfactory receptors olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Function

The OR2G6 gene is part of the olfactory receptor family, a class of proteins that are responsible for detecting smells. These proteins are located in the cell membranes of olfactory receptor neurons in the nose and they interact with odorant molecules in the air, triggering a neuronal response.

The specific function of the OR2G6 gene is not well understood, but it is believed to play a role in the detection of certain smells. Like other olfactory receptors, it is a member of the G-protein-coupled receptor (GPCR) family. These receptors are involved in a wide range of physiological processes, including sensory perception, immune response, and regulation of mood and behavior.

Structure

The OR2G6 gene is located on chromosome 1, specifically on the long (q) arm at position 24. It spans approximately 1,000 base pairs of DNA and contains a single coding exon. The protein encoded by this gene is a member of the GPCR family, which are characterized by seven transmembrane domains, an extracellular N terminus, and an intracellular C terminus.

Clinical Significance

While the specific role of the OR2G6 gene in human health and disease is not well understood, olfactory receptors in general are being studied for their potential roles in disease. For example, changes in the sense of smell are often an early sign of neurodegenerative diseases such as Parkinson's and Alzheimer's.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Neurodegenerative disease