OR2T2

OR2T2 is a gene that encodes the olfactory receptor, family 2, subfamily T, member 2 protein in humans. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Function

Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR2T2 gene is located on the chromosome 1 (1q44) and spans 988 base pairs. The gene is expressed in the olfactory epithelium.

Clinical Significance

Variations in the OR2T2 gene have been associated with differences in olfactory function. However, further research is needed to fully understand the clinical implications of these variations.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Olfaction