OR5D14

OR5D14 is a gene that encodes a protein in humans. The protein is a member of the olfactory receptor family, a class of G protein-coupled receptors which are involved in the detection of smell.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR5D14 gene is located on chromosome 1, specifically at 1q44. It spans a length of 993 base pairs and encodes a protein that is 310 amino acids in length. The gene is expressed in a variety of tissues, with the highest expression levels found in the olfactory epithelium.

Protein

The OR5D14 protein is a member of the olfactory receptor family, which is the largest family within the class A rhodopsin-like receptors of the GPCR superfamily. Like other olfactory receptors, OR5D14 is believed to function in the detection of smell. However, the specific ligand that this receptor recognizes has not yet been identified.

Clinical significance

While the exact role of OR5D14 in disease is not well understood, olfactory receptors in general have been implicated in a variety of diseases, including neurodegenerative diseases like Parkinson's disease and Alzheimer's disease, as well as cancer. Further research is needed to determine the specific role of OR5D14 in these and other conditions.

See also

• Olfactory receptor
• G protein-coupled receptor
• Neurodegenerative disease

References

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