OSR1
OSR1 or Odd-skipped related transcription factor 1 is a protein that in humans is encoded by the OSR1 gene. This protein is a transcription factor that plays a significant role in the development and function of several organ systems in the body.
Function[edit | edit source]
OSR1 is a member of the Odd-skipped family of zinc finger transcription factors. It is involved in the regulation of mesoderm formation and kidney development. The protein is known to interact with Wt1, a transcription factor that is essential for the development of the urogenital system.
Clinical Significance[edit | edit source]
Mutations in the OSR1 gene have been associated with several medical conditions. For instance, they have been linked to congenital heart disease and renal agenesis, a condition where one or both kidneys fail to develop.
Research[edit | edit source]
Research into the role of OSR1 in embryonic development and disease is ongoing. It is hoped that a better understanding of this protein could lead to new treatments for a range of conditions.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
