OSR1

OSR1 or Odd-skipped related transcription factor 1 is a protein that in humans is encoded by the OSR1 gene. This protein is a transcription factor that plays a significant role in the development and function of several organ systems in the body.

Function

OSR1 is a member of the Odd-skipped family of zinc finger transcription factors. It is involved in the regulation of mesoderm formation and kidney development. The protein is known to interact with Wt1, a transcription factor that is essential for the development of the urogenital system.

Clinical Significance

Mutations in the OSR1 gene have been associated with several medical conditions. For instance, they have been linked to congenital heart disease and renal agenesis, a condition where one or both kidneys fail to develop.

Research

Research into the role of OSR1 in embryonic development and disease is ongoing. It is hoped that a better understanding of this protein could lead to new treatments for a range of conditions.

See Also

• Transcription factor
• Gene
• Protein
• Kidney development
• Congenital heart disease
• Renal agenesis

References

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