Ocedurenone
A nonsteroidal antimineralocorticoid medication
| Ocedurenone | |
|---|---|
| [[File:|frameless|220px|alt=|]] | |
| INN | |
| Drug class | |
| Routes of administration | |
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| CAS Number | 123456-78-9 |
| PubChem | 12345678 |
| DrugBank | DB12345 |
| ChemSpider | 123456 |
| KEGG | D12345 |
Ocedurenone is a nonsteroidal antimineralocorticoid medication that is primarily used for its diuretic and antihypertensive properties. It is a selective antagonist of the mineralocorticoid receptor, which plays a crucial role in the regulation of electrolyte and fluid balance in the body.
Mechanism of Action[edit | edit source]
Ocedurenone functions by blocking the action of aldosterone, a hormone that promotes the retention of sodium and water in the kidneys. By inhibiting aldosterone, ocedurenone facilitates the excretion of sodium and water, thereby reducing blood pressure and decreasing fluid overload in conditions such as heart failure.
Pharmacokinetics[edit | edit source]
Ocedurenone is administered orally and is well absorbed from the gastrointestinal tract. It undergoes hepatic metabolism and is primarily excreted via the renal route. The drug has a half-life that allows for once-daily dosing, making it convenient for patients.
Clinical Uses[edit | edit source]
Ocedurenone is indicated for the treatment of hypertension and edema associated with congestive heart failure, liver cirrhosis, and nephrotic syndrome. It is also being investigated for potential use in chronic kidney disease and resistant hypertension.
Side Effects[edit | edit source]
Common side effects of ocedurenone include hyperkalemia, dizziness, and gastrointestinal disturbances. Due to its mechanism of action, monitoring of serum potassium levels is recommended to prevent complications associated with elevated potassium levels.
Contraindications[edit | edit source]
Ocedurenone is contraindicated in patients with hyperkalemia, severe renal impairment, and known hypersensitivity to the drug. Caution is advised when used in conjunction with other medications that increase serum potassium levels.
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