Orthohepevirus

Orthohepevirus is a genus of viruses in the family Hepeviridae. Viruses in Orthohepevirus are non-enveloped and have single-stranded RNA genomes. The genus contains four species, which infect humans and various animals.

Taxonomy[edit | edit source]

Orthohepevirus is a genus in the family Hepeviridae. The genus contains four species: Orthohepevirus A, Orthohepevirus B, Orthohepevirus C, and Orthohepevirus D. Orthohepevirus A is further divided into eight genotypes.

Structure[edit | edit source]

Viruses in Orthohepevirus are non-enveloped, with icosahedral geometries, and T=3 symmetry. The diameter is around 27-34 nm. Genomes are linear and non-segmented, around 7.2 kb in length.

Life Cycle[edit | edit source]

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Humans and various animals serve as the natural host.

Clinical[edit | edit source]

Orthohepevirus A is the causative agent of hepatitis E, a liver disease that can cause severe illness in pregnant women and people with weakened immune systems. The virus is transmitted through the fecal-oral route, often through contaminated water.

References[edit | edit source]

External links[edit | edit source]

Orthohepevirus at NCBI Taxonomy Browser

Orthohepevirus Resources
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