Otu deubiquitinase 5

OTU Deubiquitinase 5 (also known as OTUD5) is a protein that in humans is encoded by the OTUD5 gene. This protein is part of the OTU domain containing family of deubiquitinases, which are enzymes that remove ubiquitin from proteins.

Function

OTUD5 is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through a proteolytic mechanism. It plays a crucial role in various cellular processes, including DNA repair, cell cycle regulation, and apoptosis. OTUD5 is known to interact with DNA damage binding protein 1 (DDB1) and Cullin 4A (CUL4A) to form a protein complex that is involved in nucleotide excision repair (NER).

Clinical significance

Alterations in the OTUD5 gene have been associated with various diseases. For instance, mutations in this gene have been linked to cancer, as it plays a role in the regulation of cell proliferation and cell death.

Structure

The OTUD5 protein contains an OTU domain, which is responsible for its deubiquitinating activity. This domain is highly conserved among various species, indicating its importance in cellular function.

See also

• Deubiquitinating enzyme
• Ubiquitin
• Protein degradation