Oxametacin

Oxametacin

Oxametacin is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of pain and inflammation associated with various medical conditions. It is a derivative of indomethacin and is known for its analgesic and antipyretic properties.

Pharmacology

Oxametacin works by inhibiting the production of prostaglandins, chemicals in the body that cause inflammation and pain. It does this by blocking the action of the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. There are two types of COX enzymes, COX-1 and COX-2. Oxametacin is a non-selective inhibitor, meaning it blocks both types of enzymes.

Clinical Use

Oxametacin is used to relieve pain and inflammation in a variety of conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout. It may also be used to reduce fever and relieve minor aches and pains due to the common cold or flu.

Side Effects

Like all NSAIDs, oxametacin can cause side effects. The most common side effects include gastrointestinal problems such as stomach pain, heartburn, and nausea. More serious side effects can include ulcers, bleeding, or holes in the stomach or intestine. Oxametacin may also increase the risk of heart attack or stroke, particularly in higher doses or with long-term use.

Precautions

Before taking oxametacin, patients should inform their healthcare provider if they have a history of heart disease, stroke, ulcers, or bleeding in the stomach or intestines. Oxametacin should not be used just before or after heart bypass surgery. It should also be used with caution in patients with kidney or liver disease.

See Also

• Nonsteroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandins

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