Oxindanac

Oxindanac

Oxindanac is a non-steroidal anti-inflammatory drug (NSAID) that was developed for the treatment of pain and inflammation. It belongs to the class of indane acetic acid derivatives and functions by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins, compounds that mediate inflammation and pain.

Chemical Structure and Properties

Oxindanac is chemically known as 2-(1-oxo-2-indanyl)acetic acid. It is characterized by the presence of an indane ring system, which is a bicyclic structure consisting of a benzene ring fused to a cyclopentane ring. The molecular formula of Oxindanac is C11H10O3, and it has a molecular weight of 190.20 g/mol.

Mechanism of Action

As an NSAID, Oxindanac exerts its effects primarily through the inhibition of the cyclooxygenase enzymes, COX-1 and COX-2. These enzymes are responsible for the conversion of arachidonic acid to prostaglandins, which are lipid compounds that play a key role in the inflammatory response. By reducing the production of prostaglandins, Oxindanac helps to alleviate symptoms of pain and inflammation.

Pharmacokinetics

Oxindanac is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily in the urine. The pharmacokinetic profile of Oxindanac includes a half-life that allows for dosing multiple times a day to maintain therapeutic levels.

Clinical Uses

Oxindanac is used in the management of various conditions associated with pain and inflammation, such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders. It may also be used for the relief of mild to moderate pain from other causes.

Side Effects

Like other NSAIDs, Oxindanac can cause a range of side effects, particularly affecting the gastrointestinal tract. Common side effects include nausea, dyspepsia, and gastric ulcers. It may also increase the risk of cardiovascular events and renal impairment with long-term use.

Contraindications

Oxindanac is contraindicated in patients with known hypersensitivity to the drug, those with a history of aspirin-induced asthma or other NSAID-related allergic reactions, and in patients with active gastrointestinal bleeding or peptic ulcer disease.

Also see

• Non-steroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandin
• Indane
• Osteoarthritis
• Rheumatoid arthritis