P2RY11
P2RY11 is a gene that encodes the P2Y11 receptor, a member of the G protein-coupled receptor family. This receptor is predominantly expressed in immune cells, where it plays a crucial role in immune response modulation.
Function[edit | edit source]
The P2RY11 gene encodes a G protein-coupled receptor that responds to extracellular adenosine diphosphate (ADP) and adenosine triphosphate (ATP). The receptor is coupled to both the Gs and Gq G proteins, which leads to the activation of both adenylyl cyclase and phospholipase C pathways. This dual coupling allows the receptor to mediate a wide range of physiological responses, including platelet aggregation, neutrophil chemotaxis, and T cell activation.
Clinical Significance[edit | edit source]
Mutations in the P2RY11 gene have been associated with a susceptibility to autoimmune diseases, including Graves' disease and systemic lupus erythematosus. The receptor's role in immune response modulation makes it a potential target for the development of new immunotherapy treatments.
See Also[edit | edit source]
- P2Y receptor
- G protein-coupled receptor
- Adenosine diphosphate
- Adenosine triphosphate
- Graves' disease
- Systemic lupus erythematosus
References[edit | edit source]
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