P2RY11

P2RY11 is a gene that encodes the P2Y purinoceptor 11, a member of the P2Y receptor family of G protein-coupled receptors. These receptors are activated by extracellular nucleotides such as ATP and ADP.

Function

The P2RY11 receptor is involved in various physiological processes, including the regulation of immune response, inflammation, and cell proliferation. It is known to couple with both Gq and Gs proteins, leading to the activation of multiple intracellular signaling pathways.

Expression

P2RY11 is expressed in a variety of tissues, with notable expression in the immune system, including leukocytes. Its expression is also observed in the central nervous system, suggesting a role in neurotransmission and neuroinflammation.

Clinical Significance

Alterations in P2RY11 expression or function have been implicated in several diseases, including autoimmune disorders and neurological conditions. Research is ongoing to explore its potential as a therapeutic target in these diseases.

See also

• P2Y receptor
• G protein-coupled receptor
• ATP
• ADP

External links

• P2RY11 on WikiMD
• P2RY11 gene information at NCBI