P2RY14

P2RY14 is a protein that in humans is encoded by the P2RY14 gene. This protein is a member of the G protein-coupled receptor family, and has been identified as a receptor for uridine diphosphate (UDP) glucose, hence it is also referred to as the UDP-glucose receptor.

Function

The P2RY14 receptor is activated by UDP-glucose and other nucleotide sugars, which are important intermediates in metabolic pathways. Upon activation, this receptor is known to inhibit adenylate cyclase activity and lead to the activation of phospholipase C and elevation of intracellular calcium levels. The receptor may also play a role in immune response as it is proposed to be capable of inhibiting the migration of neutrophils.

Clinical significance

Alterations in the P2RY14 gene have been associated with a variety of diseases. For instance, a study has suggested that variations in this gene may be associated with asthma susceptibility. Moreover, the P2RY14 receptor has been implicated in the regulation of platelet aggregation, suggesting a potential role in thrombosis.

See also

• P2Y receptor
• G protein-coupled receptor
• Uridine diphosphate glucose

External links

• GeneCards: P2RY14

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