PANO1
Human gene encoding a long non-coding RNA
PANO1[edit | edit source]
PANO1 is a gene in humans that encodes a long non-coding RNA (lncRNA). This gene is located on chromosome 11 and is involved in various cellular processes, although its exact function is not fully understood. PANO1 is of interest in the study of cancer and other diseases due to its potential regulatory roles.
Structure[edit | edit source]
The PANO1 gene is transcribed into a long non-coding RNA, which means it does not encode a protein. However, the RNA itself may have structural motifs that are important for its function. The secondary structure of PANO1 RNA can be predicted using computational tools, revealing potential stem-loop structures and other motifs that may be involved in RNA-RNA or RNA-protein interactions.
The secondary structure of PANO1 is characterized by several hairpin loops and bulges, which are typical features of functional RNA molecules. These structures may play a role in the stability and function of the RNA.
Function[edit | edit source]
The exact function of PANO1 is not fully elucidated, but as a long non-coding RNA, it is likely involved in the regulation of gene expression. LncRNAs can act as molecular scaffolds, decoys, or guides, influencing the activity of other molecules such as transcription factors, microRNAs, and chromatin modifiers.
Evolution[edit | edit source]
PANO1 is conserved across several species, indicating that it may have important biological functions. The evolutionary tree of PANO1 shows its presence in various mammals, suggesting that it has been maintained through evolutionary pressures.
Clinical significance[edit | edit source]
PANO1 has been studied in the context of cancer, where it may play a role in tumor progression or suppression. The expression levels of PANO1 could potentially serve as a biomarker for certain types of cancer, although more research is needed to confirm its clinical utility.
Genomic context[edit | edit source]
PANO1 is located on chromosome 11, and its genomic context includes several other genes and regulatory elements. Understanding the genomic neighborhood of PANO1 can provide insights into its potential interactions and regulatory mechanisms.
Related pages[edit | edit source]
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Contributors: Prab R. Tumpati, MD
