PB-22

PB-22 is a synthetic cannabinoid that is used as an active ingredient in synthetic cannabis products. It was first identified in 2013 in samples of synthetic cannabis products sold in Japan. PB-22 is an analog of JWH-018 which has a quinolinyl group, instead of a naphthoyl group. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.

Chemistry[edit | edit source]

PB-22 is a derivative of JWH-018, but instead of a naphthoyl group, it has a quinolinyl group. The structure of PB-22 is related to that of other synthetic cannabinoids, including AM-2201, AM-694, AM-1241, and AM-2233. It is a white, crystalline powder that is soluble in organic solvents.

Pharmacology[edit | edit source]

The pharmacological properties of PB-22 are not well-studied. However, it is known to act as a potent agonist for the CB1 receptor, with a Ki of 5.2 nM. This makes it roughly equivalent in potency to JWH-018, although the effects in humans are not known.

Legal status[edit | edit source]

PB-22 is a Schedule I controlled substance in the United States, and is also controlled in many other countries. It is illegal to manufacture, distribute, or possess PB-22 in these jurisdictions.

See also[edit | edit source]

PB-22 Resources
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