PDGFC
PDGFC (Platelet Derived Growth Factor C) is a protein that in humans is encoded by the PDGFC gene. This protein is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines.
Function[edit | edit source]
The PDGFC protein is a potent mitogen for cells of mesenchymal origin. It functions by binding to its receptor, PDGFR-α, and inducing its dimerization. This leads to the activation of the receptor's intrinsic tyrosine kinase activity, which in turn triggers a series of downstream signaling events. These events promote cell proliferation, survival, and migration, and they play a crucial role in the development and maintenance of several types of tissues.
Clinical significance[edit | edit source]
Mutations in the PDGFC gene have been associated with several types of cancer, including breast cancer, lung cancer, and glioblastoma. In addition, overexpression of PDGFC has been observed in a variety of tumors, suggesting that it may play a role in tumor growth and progression.
See also[edit | edit source]
References[edit | edit source]
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