PHI-base
PHI-base is a web-accessible database that catalogues experimentally verified pathogenicity, virulence and effector genes from fungal, Oomycete and bacterial pathogens, which infect animal, plant, fungal and insect hosts. PHI-base is therapeutically relevant to researchers worldwide, aiding the identification of targets for chemical intervention. If a particular gene is essential for a pathogen's survival, knowledge of its structure can enable the design of chemical inhibitors, leading to disease control.
Overview[edit | edit source]
PHI-base contains information on pathogenicity, virulence and effector genes from various pathogens. The database is freely available and can be accessed online. It is a valuable resource for researchers studying pathogenicity, virulence, and effector genes, as well as those working in related fields such as genomics, proteomics, and bioinformatics.
Content[edit | edit source]
The content of PHI-base is derived from peer-reviewed literature. Each entry in the database is manually curated and provides detailed information about the gene, including its name, synonyms, functional description, and the pathogen in which it is found. The database also includes information about the host species that the pathogen infects, the disease that it causes, and any known interactions between the gene and host proteins.
Applications[edit | edit source]
PHI-base is used by researchers worldwide to identify potential targets for chemical intervention in the treatment of various diseases. By understanding the structure of essential pathogen genes, researchers can design chemical inhibitors that can control the disease.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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