PHI-base
A database of pathogen-host interactions
Overview[edit | edit source]
PHI-base (Pathogen-Host Interactions database) is a comprehensive online resource that catalogues experimentally verified pathogenicity, virulence, and effector genes from various pathogens. It serves as a critical tool for researchers studying the molecular mechanisms of infectious diseases and the interactions between pathogens and their hosts.
History[edit | edit source]
PHI-base was established to provide a centralized repository of information on pathogen-host interactions. It was developed to support the scientific community by offering access to curated data that can be used to understand the genetic basis of pathogenicity and host resistance.
Content[edit | edit source]
PHI-base contains detailed information on:
- Pathogenicity genes: Genes that are essential for a pathogen to cause disease.
- Virulence genes: Genes that enhance the severity of disease symptoms.
- Effector genes: Genes that encode proteins or molecules that manipulate host cell processes.
The database includes data from a wide range of pathogens, including bacteria, fungi, oomycetes, and viruses, and their interactions with plant, animal, and human hosts.
Functionality[edit | edit source]
PHI-base provides several features to facilitate research:
- Search and Browse: Users can search for specific genes, pathogens, or host species.
- Data Export: Researchers can download data for further analysis.
- Curation: The database is regularly updated with new findings from scientific literature.
Applications[edit | edit source]
PHI-base is used in various fields of research, including:
- Agricultural Science: Understanding plant-pathogen interactions to develop disease-resistant crops.
- Medical Research: Identifying potential targets for new antimicrobial drugs.
- Epidemiology: Studying the spread and control of infectious diseases.
Related pages[edit | edit source]
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Contributors: Prab R. Tumpati, MD
