PIM-35

PIM-35 is a type of protein kinase that plays a crucial role in cell cycle regulation and apoptosis. It is part of the PIM kinase family, which includes PIM-1, PIM-2, and PIM-3. These kinases are known for their involvement in cancer development and progression.

Function

PIM-35, like other PIM kinases, is involved in the regulation of cell growth and survival. It does this by phosphorylating a variety of target proteins, including those involved in cell cycle progression and apoptosis. This can lead to increased cell proliferation and survival, which can contribute to the development of cancer.

Role in Cancer

PIM-35 has been implicated in a variety of cancers, including prostate cancer, breast cancer, and leukemia. It is often overexpressed in these cancers, leading to increased cell growth and survival. This makes it a potential target for cancer therapy.

Therapeutic Potential

Due to its role in cancer, PIM-35 is being investigated as a potential target for cancer therapy. Several PIM kinase inhibitors are currently in development, with the aim of blocking the activity of PIM-35 and other PIM kinases. These inhibitors have shown promise in preclinical studies, and some are currently in clinical trials.

See Also

• PIM-1
• PIM-2
• PIM-3
• Protein kinase
• Cell cycle
• Apoptosis
• Cancer