POU3F2

POU3F2 (also known as Brain-2 or BRN2) is a protein that in humans is encoded by the POU3F2 gene. It is a member of the POU family of transcription factors, which play a crucial role in the regulation of gene expression.

Function

POU3F2 is a transcription factor that binds to the octamer motif (5'-ATGCAAAT-3') and activates the promoters of the genes for small nuclear RNAs (snRNA) and of genes such as those expressed in neuroendocrine cells and neurons. It may play a role in the development of the brain and nervous system.

Clinical significance

Alterations in the POU3F2 gene have been associated with susceptibility to schizophrenia and bipolar disorder. It has also been implicated in the progression of melanoma, a type of skin cancer.

Structure

The POU3F2 protein contains a POU domain, a highly conserved region found in a family of transcription factors that regulate gene expression. This domain is responsible for the protein's ability to bind to specific DNA sequences and modulate gene expression.

Expression

POU3F2 is expressed in the brain, specifically in the neocortex, hippocampus, and amygdala. It is also expressed in the pituitary gland and in melanocytes, the cells that produce melanin.

Research

Research is ongoing to understand the role of POU3F2 in the development of the brain and in various neurological and psychiatric disorders. It is also being studied for its potential role in the progression of melanoma.

File:POU3F2 protein structure.jpg

Structure of the POU3F2 protein. Image from Wikimedia Commons.

See also

• POU domain
• Transcription factor
• Schizophrenia
• Bipolar disorder
• Melanoma