PVRL2

PVRL2 (Poliovirus Receptor-Related 2), also known as Nectin-2 and CD112 (Cluster of Differentiation 112), is a human gene. The protein encoded by this gene is a member of the nectin family and is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It functions as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses.

Function

The PVRL2 gene encodes a member of the nectin family of proteins, which function as cell adhesion molecules. These proteins are implicated in various biological processes, including cell migration, organization and differentiation, and they are involved in the formation of adherens junctions and tight junctions. The encoded protein is a single-pass type I membrane protein and acts as a receptor for herpes simplex virus (HSV). It can also mediate cell-cell adhesion through both homophilic and heterophilic interactions.

Clinical significance

Mutations in the PVRL2 gene have been associated with cleft lip/palate-ectodermal dysplasia syndrome (CLPED1). Additionally, the PVRL2 protein can be used by some viruses for cell entry. For example, the herpes simplex virus (HSV) and pseudorabies virus (PRV) can use PVRL2 as a receptor to enter cells.

Interactions

PVRL2 has been shown to interact with:

• AF-6
• PVR
• PVRL3
• PVRL1

External links

• PVRL2 at the US National Library of Medicine Medical Subject Headings (MeSH)

PVRL2 Resources
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