Poliovirus
Poliovirus is a member of the family Picornaviridae and the genus Enterovirus. It is an RNA virus that causes poliomyelitis, a disease that can lead to paralysis.
Structure[edit | edit source]
Poliovirus is a non-enveloped virus with an icosahedral symmetry. Its capsid is composed of 60 copies each of four different viral proteins. The genome of the poliovirus is a single-stranded positive-sense RNA molecule approximately 7500 nucleotides long.
Life Cycle[edit | edit source]
The life cycle of the poliovirus begins when it attaches to a receptor on the surface of a host cell. The virus then enters the cell and uncoats its RNA genome. The RNA is translated into a polyprotein, which is then cleaved into individual viral proteins. These proteins and the viral RNA assemble into new virus particles, which are released from the cell to infect other cells.
Pathogenesis[edit | edit source]
Poliovirus primarily infects the gastrointestinal tract, but it can also spread to the central nervous system and cause paralysis. The virus is transmitted through the fecal-oral route, and it can survive in the environment for several weeks.
Prevention and Treatment[edit | edit source]
There is no cure for poliomyelitis, but it can be prevented with the polio vaccine. There are two types of polio vaccines: the inactivated polio vaccine (IPV) and the oral polio vaccine (OPV). Both vaccines stimulate the immune system to produce antibodies against the poliovirus.
See Also[edit | edit source]
References[edit | edit source]
Poliovirus Resources | ||
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