Panipenem

Panipenem is a carbapenem antibiotic that is often used in combination with betamipron, a renal dehydropeptidase inhibitor. This combination is used to prevent the degradation of panipenem in the kidneys. Panipenem/betamipron is marketed under the brand name Carbapenem in Japan.

Medical uses

Panipenem is used to treat a variety of bacterial infections, including those caused by Gram-positive bacteria and Gram-negative bacteria. It is particularly effective against Pseudomonas aeruginosa, Enterobacteriaceae, and Staphylococcus aureus.

Pharmacology

Panipenem works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria.

Side effects

Common side effects of panipenem include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause more serious side effects such as anaphylaxis, a severe allergic reaction.

History

Panipenem was first approved for medical use in Japan in 1993. It is not currently approved for use in the United States.

See also

• List of antibiotics
• Carbapenem resistance

Panipenem Resources
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